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Sorafenib inhibits interferon production by plasmacytoid dendritic cells in hepatocellular carcinoma

BACKGROUND: Sorafenib is a multi-kinase inhibitor that shows antitumor activity in advanced hepatocellular carcinoma. Sorafenib exerts a regulatory effect on immune cells, including T cells, natural killer cells and dendritic cells. Studies have shown that plasmacytoid dendritic cells (pDCs) are fun...

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Detalles Bibliográficos
Autores principales: Zhang, Xinning, Xu, Yong, Zhao, Guodong, Liu, Rong, Yu, Haisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710007/
https://www.ncbi.nlm.nih.gov/pubmed/36451110
http://dx.doi.org/10.1186/s12885-022-10356-2