MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions

DNA loop extrusion emerges as a key process establishing genome structure and function. We introduce MoDLE, a computational tool for fast, stochastic modeling of molecular contacts from DNA loop extrusion capable of simulating realistic contact patterns genome wide in a few minutes. MoDLE accurately...

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Detalles Bibliográficos
Autores principales: Rossini, Roberto, Kumar, Vipin, Mathelier, Anthony, Rognes, Torbjørn, Paulsen, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710047/
https://www.ncbi.nlm.nih.gov/pubmed/36451166
http://dx.doi.org/10.1186/s13059-022-02815-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710047/
https://www.ncbi.nlm.nih.gov/pubmed/36451166
http://dx.doi.org/10.1186/s13059-022-02815-7

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