Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor

PARP16—the sole ER-resident PARP family member—is gaining attention as a potential therapeutic target for cancer treatment. Nevertheless, the precise function of the catalytic activity of PARP16 is poorly understood. This is primarily due to the lack of inhibitors that are selective for PARP16 over...

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Detalles Bibliográficos
Autores principales: Bejan, Daniel S., Sundalam, Sunil, Jin, Haihong, Morgan, Rory K., Kirby, Ilsa T., Siordia, Ivan R., Tivon, Barr, London, Nir, Cohen, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710212/
https://www.ncbi.nlm.nih.gov/pubmed/36544740
http://dx.doi.org/10.1039/d2sc04820e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710212/
https://www.ncbi.nlm.nih.gov/pubmed/36544740
http://dx.doi.org/10.1039/d2sc04820e

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