Inhibition of microRNA-200c preserves astrocyte sirtuin-1 and mitofusin-2, and protects against hippocampal neurodegeneration following global cerebral ischemia in mice

Memory impairment remains a leading disability in survivors of global cerebral ischemia, occurring secondary to delayed neurodegeneration of hippocampal cornu ammonis-1 (CA1) neurons. MicroRNA-200c (miR-200c) is induced following ischemic stress and we have previously demonstrated that pre-treatment...

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Detalles Bibliográficos
Autores principales: Griffiths, Brian, Xu, Lijun, Sun, Xiaoyun, Greer, Majesty, Murray, Isabella, Stary, Creed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710226/
https://www.ncbi.nlm.nih.gov/pubmed/36466801
http://dx.doi.org/10.3389/fnmol.2022.1014751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710226/
https://www.ncbi.nlm.nih.gov/pubmed/36466801
http://dx.doi.org/10.3389/fnmol.2022.1014751

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