MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST

The mediator of IRF3 activation (MITA, also named STING) is critical for immune responses to abnormal cytosolic DNA and has been considered an important drug target in the clinical therapy of tumors and autoimmune diseases. In the present study, we report that MITA undergoes DDOST-mediated N-glycosy...

Descripción completa

Detalles Bibliográficos
Autores principales: Tu, Yi, Yin, Xiu-Juan, Liu, Qian, Zhang, Shan, Wang, Jie, Ji, Ben-Zhe, Zhang, Jie, Sun, Ming-Shun, Yang, Yang, Wang, Chen-Hui, Yin, Lei, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710844/
https://www.ncbi.nlm.nih.gov/pubmed/36449507
http://dx.doi.org/10.1371/journal.ppat.1010989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710844/
https://www.ncbi.nlm.nih.gov/pubmed/36449507
http://dx.doi.org/10.1371/journal.ppat.1010989

Ejemplares similares