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MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST
The mediator of IRF3 activation (MITA, also named STING) is critical for immune responses to abnormal cytosolic DNA and has been considered an important drug target in the clinical therapy of tumors and autoimmune diseases. In the present study, we report that MITA undergoes DDOST-mediated N-glycosy...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710844/ https://www.ncbi.nlm.nih.gov/pubmed/36449507 http://dx.doi.org/10.1371/journal.ppat.1010989 |