Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by defective regulatory T (T(reg)) cells. Here, we demonstrate that a T cell–specific deletion of calcium/calmodulin-dependent protein kinase 4 (CaMK4) improves disease in B6.lpr lupus-prone mice and expands T(reg) cells. Mech...

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Detalles Bibliográficos
Autores principales: Scherlinger, Marc, Pan, Wenliang, Hisada, Ryo, Boulougoura, Afroditi, Yoshida, Nobuya, Vukelic, Milena, Umeda, Masataka, Krishfield, Suzanne, Tsokos, Maria G., Tsokos, George C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710877/
https://www.ncbi.nlm.nih.gov/pubmed/36449620
http://dx.doi.org/10.1126/sciadv.adc9657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710877/
https://www.ncbi.nlm.nih.gov/pubmed/36449620
http://dx.doi.org/10.1126/sciadv.adc9657

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