Decreasing Wapl dosage partially corrects embryonic growth and brain transcriptome phenotypes in Nipbl(+/−) embryos

Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for NIPBL causes a developmental disorder, Cornelia de Lange syndrome (CdLS), that is modeled by Nipbl(+/−) mice. Mutations in WAPL have...

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Detalles Bibliográficos
Autores principales: Kean, Connor M., Tracy, Christopher J., Mitra, Apratim, Rahat, Beenish, Van Winkle, Matthew T., Gebert, Claudia M., Noeker, Jacob A., Calof, Anne L., Lander, Arthur D., Kassis, Judith A., Pfeifer, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710879/
https://www.ncbi.nlm.nih.gov/pubmed/36449618
http://dx.doi.org/10.1126/sciadv.add4136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710879/
https://www.ncbi.nlm.nih.gov/pubmed/36449618
http://dx.doi.org/10.1126/sciadv.add4136

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