Cargando…

Decreasing Wapl dosage partially corrects embryonic growth and brain transcriptome phenotypes in Nipbl(+/−) embryos

Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for NIPBL causes a developmental disorder, Cornelia de Lange syndrome (CdLS), that is modeled by Nipbl(+/−) mice. Mutations in WAPL have...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kean, Connor M., Tracy, Christopher J., Mitra, Apratim, Rahat, Beenish, Van Winkle, Matthew T., Gebert, Claudia M., Noeker, Jacob A., Calof, Anne L., Lander, Arthur D., Kassis, Judith A., Pfeifer, Karl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710879/ https://www.ncbi.nlm.nih.gov/pubmed/36449618 http://dx.doi.org/10.1126/sciadv.add4136

Ejemplares similares

The glucocorticoid receptor associates with the cohesin loader NIPBL to promote long-range gene regulation
por: Rinaldi, Lorenzo, et al.
Publicado: (2022)

Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression
por: Luppino, Jennifer M., et al.
Publicado: (2022)

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA
por: Park, Ki-Sun, et al.
Publicado: (2021)

Nipbl and Mediator Cooperatively Regulate Gene Expression to Control Limb Development
por: Muto, Akihiko, et al.
Publicado: (2014)

Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites
por: de Prisco, Nicola, et al.
Publicado: (2023)

Multifactorial Origins of Heart and Gut Defects in nipbl-Deficient Zebrafish, a Model of Cornelia de Lange Syndrome
por: Muto, Akihiko, et al.
Publicado: (2011)

In vivo acoustic manipulation of microparticles in zebrafish embryos
por: Jooss, Viktor Manuel, et al.
Publicado: (2022)

Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I
por: Visnes, T., et al.
Publicado: (2013)

ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer
por: Li, Dan, et al.
Publicado: (2023)

Transcript accumulation rates in the early Caenorhabditis elegans embryo
por: Sivaramakrishnan, Priya, et al.
Publicado: (2023)

Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA
por: Park, Ki-Sun, et al.
Publicado: (2017)

Small RNAs couple embryonic developmental programs to gut microbes
por: Ohno, Hayao, et al.
Publicado: (2022)

Extensive programmed centriole elimination unveiled in C. elegans embryos
por: Kalbfuss, Nils, et al.
Publicado: (2023)

Recycling of parental histones preserves the epigenetic landscape during embryonic development
por: Mühlen, Dominik, et al.
Publicado: (2023)

Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
por: Tiana, María, et al.
Publicado: (2022)

TDP-43 safeguards the embryo genome from L1 retrotransposition
por: Li, Ten D., et al.
Publicado: (2022)

Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs
por: Wu, Xiaotong, et al.
Publicado: (2021)

Primary specification of blastocyst trophectoderm by scRNA-seq: New insights into embryo implantation
por: Liu, Dandan, et al.
Publicado: (2022)

Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development
por: Adhikari, Deepak, et al.
Publicado: (2022)

Single-cell multiomics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection
por: Wang, Jing, et al.
Publicado: (2022)

Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo
por: Chuai, Manli, et al.
Publicado: (2023)

Mature mRNA processing that deletes 3′ end sequences directs translational activation and embryonic development
por: Takada, Yuki, et al.
Publicado: (2023)

Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting
por: Lu, Xukun, et al.
Publicado: (2021)

Developmentally programmed histone H3 expression regulates cellular plasticity at the parental-to-early embryo transition
por: Gleason, Ryan J., et al.
Publicado: (2023)

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities
por: Liu, Chao, et al.
Publicado: (2023)

Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo
por: Cooper, Rory L., et al.
Publicado: (2023)

5′ Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos
por: Chen, Luxi, et al.
Publicado: (2021)

CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles
por: Cavalheiro, Gabriel R., et al.
Publicado: (2023)

A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging
por: Sonowal, Robert, et al.
Publicado: (2023)

Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos
por: Nkombo Nkoula, Sylvia, et al.
Publicado: (2023)

Lnc956 regulates mouse embryonic stem cell differentiation in response to DNA damage in a p53-independent pathway
por: Ma, Huaixiao, et al.
Publicado: (2023)

ATP-binding cassette protein ABCF1 couples transcription and genome surveillance in embryonic stem cells through low-complexity domain
por: Choi, Eun-Bee, et al.
Publicado: (2021)

Concordance of hydrogen peroxide–induced 8-oxo-guanine patterns with two cancer mutation signatures of upper GI tract tumors
por: Jin, Seung-Gi, et al.
Publicado: (2022)

Coevolution of the Ess1-CTD axis in polar fungi suggests a role for phase separation in cold tolerance
por: Palumbo, Ryan J., et al.
Publicado: (2022)

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects
por: Santos, Rosaysela, et al.
Publicado: (2016)

Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus
por: Herb, Brian R., et al.
Publicado: (2023)

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias
por: Yen, Yu-Chen, et al.
Publicado: (2022)

EV-D68 virus-like particle vaccines elicit cross-clade neutralizing antibodies that inhibit infection and block dissemination
por: Krug, Peter W., et al.
Publicado: (2023)

Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function
por: Brown, Matthew R., et al.
Publicado: (2021)

Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl (+/−) Mouse, a Model of Cornelia de Lange Syndrome
por: Kawauchi, Shimako, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_86id71er6qjkcerc6jmm2q9p7d