Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not well defined. Here, we show that sfRNA is required for transp...

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Detalles Bibliográficos
Autores principales: Slonchak, Andrii, Wang, Xiaohui, Aguado, Julio, Sng, Julian D. J., Chaggar, Harman, Freney, Morgan E., Yan, Kexin, Torres, Francisco J., Amarilla, Alberto A., Balea, Rickyle, Setoh, Yin Xiang, Peng, Nias, Watterson, Daniel, Wolvetang, Ernst, Suhrbier, Andreas, Khromykh, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710884/
https://www.ncbi.nlm.nih.gov/pubmed/36449607
http://dx.doi.org/10.1126/sciadv.add8095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710884/
https://www.ncbi.nlm.nih.gov/pubmed/36449607
http://dx.doi.org/10.1126/sciadv.add8095

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