Cargando…

Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation

Epithelial cells usually trigger their “migratory machinery” upon loss of adhesion to their neighbors. This default is important for both physiological (e.g., wound healing) and pathological (e.g., tumor metastasis) processes. However, the underlying mechanism for such a default remains unclear. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yu-Hsuan, Hsu, Jinn-Yuan, Chu, Ching-Tung, Chang, Yao-Wen, Fan, Jia-Rong, Yang, Muh-Hwa, Chen, Hong-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711860/ https://www.ncbi.nlm.nih.gov/pubmed/36446524 http://dx.doi.org/10.26508/lsa.202201529

Ejemplares similares

Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment
por: Pantarelli, Chiara, et al.
Publicado: (2018)

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation
por: Steffen, Anika, et al.
Publicado: (2013)

Rac Activation by the T-Cell Receptor Inhibits T Cell Migration
por: Cernuda-Morollón, Eva, et al.
Publicado: (2010)

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion
por: Vaughan, Lynsey, et al.
Publicado: (2014)

Centrosome guides spatial activation of Rac to control cell polarization and directed cell migration
por: Cheng, Hung-Wei, et al.
Publicado: (2019)

Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration
por: Su, Chia-Yi, et al.
Publicado: (2019)

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase
por: Sander, Eva E., et al.
Publicado: (1998)

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells
por: Takaishi, Kenji, et al.
Publicado: (1997)

Rah, rah, ROS: metabolic changes caused by loss of adhesion induce cell death
por: Young, Christian D, et al.
Publicado: (2009)

RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration
por: Goldfinger, Lawrence E., et al.
Publicado: (2006)

FGF5 Regulates Schwann Cell Migration and Adhesion
por: Chen, Bing, et al.
Publicado: (2020)

Two Rac1 pools integrate the direction and coordination of collective cell migration
por: Zhou, Sijia, et al.
Publicado: (2022)

SUMOylation of the GTPase Rac1 is required for optimal cell migration
por: Castillo-Lluva, Sonia, et al.
Publicado: (2010)

Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling
por: Jeong, SukYeong, et al.
Publicado: (2017)

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation
por: Myant, Kevin B., et al.
Publicado: (2013)

Rac1 and Rac3 GTPases Regulate the Development of Hilar Mossy Cells by Affecting the Migration of Their Precursors to the Hilus
por: Pennucci, Roberta, et al.
Publicado: (2011)

Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells
por: Bhat, H F, et al.
Publicado: (2014)

RacA-Mediated ROS Signaling Is Required for Polarized Cell Differentiation in Conidiogenesis of Aspergillus fumigatus
por: Chi, Myoung-Hwan, et al.
Publicado: (2016)

Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell–cell adhesion
por: Yamada, Soichiro, et al.
Publicado: (2007)

Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness
por: Le, Lily Thao-Nhi, et al.
Publicado: (2016)

Distinct predictive performance of Rac1 and Cdc42 in cell migration
por: Yamao, Masataka, et al.
Publicado: (2015)

The RacGAP β-Chimaerin is essential for cerebellar granule cell migration
por: Estep, Jason A., et al.
Publicado: (2018)

Stuck in the middle: Rac, adhesion, and cytokinesis
por: Davies, Tim, et al.
Publicado: (2012)

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration
por: Amelio, Ivano, et al.
Publicado: (2012)

Coordination between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac1
por: Hirata, Hiroaki, et al.
Publicado: (2020)

Fibronectin in cell adhesion and migration via N-glycosylation
por: Hsiao, Cheng-Te, et al.
Publicado: (2017)

Rapid Suppression of Activated Rac1 by Cadherins and Nectins during De Novo Cell-Cell Adhesion
por: Kitt, Khameeka N., et al.
Publicado: (2011)

TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b
por: Melzer, Catharina, et al.
Publicado: (2017)

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
por: Marei, Hadir, et al.
Publicado: (2016)

Cell cycling with Rac
por: Powledge, Tabitha M.
Publicado: (2001)

A Rac switch regulates random versus directionally persistent cell migration
por: Pankov, Roumen, et al.
Publicado: (2005)

CD81 regulates cell migration through its association with Rac GTPase
por: Tejera, Emilio, et al.
Publicado: (2013)

Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration
por: Dirat, Béatrice, et al.
Publicado: (2014)

Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation
por: Fionda, Cinzia, et al.
Publicado: (2021)

Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells
por: Wang, Dan, et al.
Publicado: (2016)

Living cell imaging and Rac1-GTP levels of CXCL12-treated migrating neural progenitor cells in stripe assay
por: Zhang, Min, et al.
Publicado: (2015)

Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration
por: Bourguignon, Lilly Y.W., et al.
Publicado: (2000)

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes
por: Daugaard, Mads, et al.
Publicado: (2013)

Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells
por: Bryant, Patrick W., et al.
Publicado: (2012)

Additive effects of simulated microgravity and ionizing radiation in cell death, induction of ROS and expression of RAC2 in human bronchial epithelial cells
por: Tan, Shaobo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9g10v5gq1ect19shvoqfqaeq9q