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Protective α1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation

BACKGROUND: Antineutrophil cytoplasmic autoantibody–associated (ANCA-associated) vasculitidies (AAV) are life-threatening systemic autoimmune conditions. ANCAs directed against proteinase 3 (PR3) or myeloperoxidase (MPO) bind their cell surface-presented antigen, activate neutrophils, and cause vasc...

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Detalles Bibliográficos
Autores principales:	Ebert, Maximilian, Jerke, Uwe, Eulenberg-Gustavus, Claudia, Kling, Lovis, Jenne, Dieter, Kirchner, Marieluise, Mertins, Philipp, Bieringer, Markus, Elitok, Saban, Eckardt, Kai-Uwe, Schreiber, Adrian, Salama, Alan D., Kettritz, Ralph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711875/ https://www.ncbi.nlm.nih.gov/pubmed/36125911 http://dx.doi.org/10.1172/JCI160089

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