A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model

Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial abnormalities, but the mechanism underlying the axonal pathology is unknown. Sterile α and Toll/IL-1 receptor motif–containing 1 (SA...

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Detalles Bibliográficos
Autores principales: Sato-Yamada, Yurie, Strickland, Amy, Sasaki, Yo, Bloom, Joseph, DiAntonio, Aaron, Milbrandt, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711878/
https://www.ncbi.nlm.nih.gov/pubmed/36287202
http://dx.doi.org/10.1172/JCI161566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711878/
https://www.ncbi.nlm.nih.gov/pubmed/36287202
http://dx.doi.org/10.1172/JCI161566

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