Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice

Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood. In this study, we found that neuropathic pain is abrogated when the kynu...

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Detalles Bibliográficos
Autores principales: Maganin, Alexandre G., Souza, Guilherme R., Fonseca, Miriam D., Lopes, Alexandre H., Guimarães, Rafaela M., Dagostin, André, Cecilio, Nerry T., Mendes, Atlante S., Gonçalves, William A., Silva, Conceição E.A., Fernandes Gomes, Francisco Isaac, Mauriz Marques, Lucas M., Silva, Rangel L., Arruda, Letícia M., Santana, Denis A., Lemos, Henrique, Huang, Lei, Davoli-Ferreira, Marcela, Santana-Coelho, Danielle, Sant’Anna, Morena B., Kusuda, Ricardo, Talbot, Jhimmy, Pacholczyk, Gabriela, Buqui, Gabriela A., Lopes, Norberto P., Alves-Filho, Jose C., Leão, Ricardo M., O’Connor, Jason C., Cunha, Fernando Q., Mellor, Andrew, Cunha, Thiago M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711882/
https://www.ncbi.nlm.nih.gov/pubmed/36227694
http://dx.doi.org/10.1172/JCI153805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711882/
https://www.ncbi.nlm.nih.gov/pubmed/36227694
http://dx.doi.org/10.1172/JCI153805

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