Macrophage depletion blocks congenital SARM1-dependent neuropathy

Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. We identified 2 rare NMNAT2 missense variants in 2 brothers afflicted with a progressive neuropathy syndrome. T...

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Detalles Bibliográficos
Autores principales: Dingwall, Caitlin B., Strickland, Amy, Yum, Sabrina W., Yim, Aldrin K.Y., Zhu, Jian, Wang, Peter L., Yamada, Yurie, Schmidt, Robert E., Sasaki, Yo, Bloom, A. Joseph, DiAntonio, Aaron, Milbrandt, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711884/
https://www.ncbi.nlm.nih.gov/pubmed/36287209
http://dx.doi.org/10.1172/JCI159800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711884/
https://www.ncbi.nlm.nih.gov/pubmed/36287209
http://dx.doi.org/10.1172/JCI159800

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