Structural basis of tankyrase activation by polymerization

The poly-ADP-ribosyltransferase tankyrase (TNKS, TNKS2) controls a wide range of disease-relevant cellular processes, including WNT–β-catenin signalling, telomere length maintenance, Hippo signalling, DNA damage repair and glucose homeostasis(1,2). This has incentivized the development of tankyrase...

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Detalles Bibliográficos
Autores principales: Pillay, Nisha, Mariotti, Laura, Zaleska, Mariola, Inian, Oviya, Jessop, Matthew, Hibbs, Sam, Desfosses, Ambroise, Hopkins, Paul C. R., Templeton, Catherine M., Beuron, Fabienne, Morris, Edward P., Guettler, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712121/
https://www.ncbi.nlm.nih.gov/pubmed/36418402
http://dx.doi.org/10.1038/s41586-022-05449-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712121/
https://www.ncbi.nlm.nih.gov/pubmed/36418402
http://dx.doi.org/10.1038/s41586-022-05449-8

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