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Structural basis of tankyrase activation by polymerization

The poly-ADP-ribosyltransferase tankyrase (TNKS, TNKS2) controls a wide range of disease-relevant cellular processes, including WNT–β-catenin signalling, telomere length maintenance, Hippo signalling, DNA damage repair and glucose homeostasis(1,2). This has incentivized the development of tankyrase...

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Detalles Bibliográficos
Autores principales:	Pillay, Nisha, Mariotti, Laura, Zaleska, Mariola, Inian, Oviya, Jessop, Matthew, Hibbs, Sam, Desfosses, Ambroise, Hopkins, Paul C. R., Templeton, Catherine M., Beuron, Fabienne, Morris, Edward P., Guettler, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712121/ https://www.ncbi.nlm.nih.gov/pubmed/36418402 http://dx.doi.org/10.1038/s41586-022-05449-8

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