Genetic and phenotypic stability of poliovirus shed from infants who received novel type 2 or Sabin type 2 oral poliovirus vaccines in Panama: an analysis of two clinical trials

BACKGROUND: Sabin strains used in oral poliovirus vaccines (OPV) can revert to virulence and, in rare instances, cause disease or generate vaccine-derived strains leading to outbreaks in areas of low immunisation coverage. A novel OPV2 (nOPV2) was designed to stabilise the viral genome against rever...

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Detalles Bibliográficos
Autores principales: Wahid, Rahnuma, Mercer, Laina D, De Leon, Tirza, DeAntonio, Rodrigo, Sáez-Llorens, Xavier, Macadam, Andrew, Chumakov, Konstantin, Strating, Jeroen, Koel, Björn, Konopka-Anstadt, Jennifer L, Oberste, M Steven, Burns, Cara C, Andino, Raul, Tritama, Erman, Bandyopadhyay, Ananda S, Aguirre, Gabriela, Rüttimann, Ricardo, Gast, Chris, Konz, John O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712124/
https://www.ncbi.nlm.nih.gov/pubmed/36332645
http://dx.doi.org/10.1016/S2666-5247(22)00254-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712124/
https://www.ncbi.nlm.nih.gov/pubmed/36332645
http://dx.doi.org/10.1016/S2666-5247(22)00254-3

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