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Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development

BACKGROUND: The path to childhood asthma is thought to initiate in utero and be further promoted by postnatal exposures. However, the underlying mechanisms remain underexplored. We hypothesized that prenatal maternal immune dysfunction associated with increased childhood asthma risk (revealed by low...

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Detalles Bibliográficos
Autores principales: DeVries, Avery, McCauley, Kathryn, Fadrosh, Douglas, Fujimura, Kei E., Stern, Debra A., Lynch, Susan V., Vercelli, Donata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712226/
https://www.ncbi.nlm.nih.gov/pubmed/35841380
http://dx.doi.org/10.1111/all.15442