Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation

Chronic hypoxia leads to irreversible cognitive impairment, primarily due to hippocampal neurodegeneration, for which the underlying mechanism remains poorly understood. We administered hypoxia (13%) to C57BL mice for 1–14 days in this study. Chronic hypoxia for 7 or 14 d, but not 1 or 3 d, resulted...

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Detalles Bibliográficos
Autores principales: Li, Gaifen, Liu, Jia, Guo, Mengyuan, Gu, Yakun, Guan, Yuying, Shao, Qianqian, Ma, Wei, Ji, Xunming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712431/
https://www.ncbi.nlm.nih.gov/pubmed/36450714
http://dx.doi.org/10.1038/s41420-022-01260-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712431/
https://www.ncbi.nlm.nih.gov/pubmed/36450714
http://dx.doi.org/10.1038/s41420-022-01260-6

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