Cargando…

Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation

Chronic hypoxia leads to irreversible cognitive impairment, primarily due to hippocampal neurodegeneration, for which the underlying mechanism remains poorly understood. We administered hypoxia (13%) to C57BL mice for 1–14 days in this study. Chronic hypoxia for 7 or 14 d, but not 1 or 3 d, resulted...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Gaifen, Liu, Jia, Guo, Mengyuan, Gu, Yakun, Guan, Yuying, Shao, Qianqian, Ma, Wei, Ji, Xunming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712431/ https://www.ncbi.nlm.nih.gov/pubmed/36450714 http://dx.doi.org/10.1038/s41420-022-01260-6

Ejemplares similares

Intermittent hypoxic conditioning restores neurological dysfunction of mice induced by long‐term hypoxia
por: Li, Gaifen, et al.
Publicado: (2022)

Hypoxic stress accelerates the propagation of pathological alpha‐synuclein and degeneration of dopaminergic neurons
por: Guo, Mengyuan, et al.
Publicado: (2022)

Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Disease
por: Guo, Mengyuan, et al.
Publicado: (2022)

Proteomic Analysis Reveals That Mitochondria Dominate the Hippocampal Hypoxic Response in Mice
por: Shao, Qianqian, et al.
Publicado: (2022)

The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation
por: Li, Gaifen, et al.
Publicado: (2021)

Effects of Hypoxia on Cerebral Microvascular Angiogenesis: Benefits or Damages?
por: Guan, Yuying, et al.
Publicado: (2023)

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
por: Zhang, Jianbin, et al.
Publicado: (2012)

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2021)

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
por: Wan, Wenbin, et al.
Publicado: (2019)

Detection of hyperphosphorylated tau protein and α-synuclein in spinal cord of patients with Alzheimer’s disease
por: Guo, Yanjun, et al.
Publicado: (2016)

HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia
por: Lei, Ling, et al.
Publicado: (2022)

Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis
por: Yudoh, Kazuo, et al.
Publicado: (2005)

The Study of Expression of Hypoxia-Inducible Factor-1 Alpha (HIF-1 Alpha) and Hypoxia-Inducible Factor-2 Alpha (HIF-2 Alpha) in Oral Squamous Cell Carcinoma: An Immunohistochemical Study
por: Mahapatra, Niva, et al.
Publicado: (2023)

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders
por: Kurzawa-Akanbi, Marzena, et al.
Publicado: (2021)

Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure
por: Chaves, Rodrigo S, et al.
Publicado: (2010)

Correction: Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis
por: Yudoh, Kazuo, et al.
Publicado: (2005)

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism
por: Singh, Rajesh K., et al.
Publicado: (2017)

Cloning and expression analysis of two distinct HIF-alpha isoforms – gcHIF-1alpha and gcHIF-4alpha – from the hypoxia-tolerant grass carp, Ctenopharyngodon idellus
por: Law, Sheran HW, et al.
Publicado: (2006)

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration
por: Merkwirth, Carsten, et al.
Publicado: (2012)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

HIF-1 suppresses lipid catabolism to promote cancer progression
por: Zhang, Huafeng
Publicado: (2015)

Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein
por: Magen, Iddo, et al.
Publicado: (2014)

New role for ceramide in hypoxia and insulin resistance
por: Xia, Qing-Song, et al.
Publicado: (2020)

Hypoxia–Induced Cytotoxic Drug Resistance in Osteosarcoma Is Independent of HIF-1Alpha
por: Adamski, Jennifer, et al.
Publicado: (2013)

Neuroprotective effects and mechanisms of ischemic/hypoxic preconditioning on neurological diseases
por: Liu, Jia, et al.
Publicado: (2021)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
por: Zhang, Xingyu, et al.
Publicado: (2021)

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress
por: Kurz, Alexander, et al.
Publicado: (2010)

Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation
por: Betzer, Cristine, et al.
Publicado: (2018)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

Impaired Baroreflex Function in Mice Overexpressing Alpha-Synuclein
por: Fleming, Sheila M., et al.
Publicado: (2013)

Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
por: Rcom-H'cheo-Gauthier, Alexandre N., et al.
Publicado: (2016)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
por: Okita, Yuho, et al.
Publicado: (2017)

Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
por: Javanshiri, Keivan, et al.
Publicado: (2022)

CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation
por: Vidanes, Genevieve M., et al.
Publicado: (2010)

Alpha synuclein in hematopoiesis and immunity
por: Pei, Yu, et al.
Publicado: (2019)

Gastrointestinal Immunity and Alpha-Synuclein
por: Barbut, Denise, et al.
Publicado: (2019)

The Membrane Interaction of Alpha-Synuclein
por: Liu, Cencen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h34vgj7j9877pllpu2esqlups6