A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance

Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based chemotherapy. The spontaneous nucleotide-excision repair of cancer cells is a representative process that leads to Pt resistance, which involves the local DNA bending to facilitate the recruitment of nucleotide-exci...

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Detalles Bibliográficos
Autores principales: Li, Fangyuan, Sun, Heng, Ren, Jiafeng, Zhang, Bo, Hu, Xi, Fang, Chunyan, Lee, Jiyoung, Gu, Hongzhou, Ling, Daishun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712435/
https://www.ncbi.nlm.nih.gov/pubmed/36450764
http://dx.doi.org/10.1038/s41467-022-35022-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712435/
https://www.ncbi.nlm.nih.gov/pubmed/36450764
http://dx.doi.org/10.1038/s41467-022-35022-w

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