Arg/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS

Most membrane-less organelles (MLOs) formed by LLPS contain both nucleic acids and IDR-rich proteins. Currently while IDRs are well-recognized to drive LLPS, nucleic acids are thought to exert non-specific electrostatic/salt effects. TDP-43 functions by binding RNA/ssDNA and its LLPS was characteriz...

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Detalles Bibliográficos
Autores principales: Dang, Mei, Li, Tongyang, Zhou, Shibo, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712531/
https://www.ncbi.nlm.nih.gov/pubmed/36450893
http://dx.doi.org/10.1038/s42003-022-04293-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712531/
https://www.ncbi.nlm.nih.gov/pubmed/36450893
http://dx.doi.org/10.1038/s42003-022-04293-w

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