Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ

DNA topoisomerase II (TOP2) is an enzyme that resolves DNA topological problems and plays critical roles in various nuclear processes. Recently, a heterozygous H58Y substitution in the ATPase domain of human TOP2B was identified from patients with autism spectrum disorder, but its biological signifi...

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Detalles Bibliográficos
Autores principales: Morotomi-Yano, Keiko, Hiromoto, Yukiko, Higaki, Takumi, Yano, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712534/
https://www.ncbi.nlm.nih.gov/pubmed/36450898
http://dx.doi.org/10.1038/s41598-022-24883-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712534/
https://www.ncbi.nlm.nih.gov/pubmed/36450898
http://dx.doi.org/10.1038/s41598-022-24883-2

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