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Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ
DNA topoisomerase II (TOP2) is an enzyme that resolves DNA topological problems and plays critical roles in various nuclear processes. Recently, a heterozygous H58Y substitution in the ATPase domain of human TOP2B was identified from patients with autism spectrum disorder, but its biological signifi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712534/ https://www.ncbi.nlm.nih.gov/pubmed/36450898 http://dx.doi.org/10.1038/s41598-022-24883-2 |