Time-resolved β-lactam cleavage by L1 metallo-β-lactamase

Serial x-ray crystallography can uncover binding events, and subsequent chemical conversions occurring during enzymatic reaction. Here, we reveal the structure, binding and cleavage of moxalactam antibiotic bound to L1 metallo-β-lactamase (MBL) from Stenotrophomonas maltophilia. Using time-resolved...

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Detalles Bibliográficos
Autores principales: Wilamowski, M., Sherrell, D. A., Kim, Y., Lavens, A., Henning, R. W., Lazarski, K., Shigemoto, A., Endres, M., Maltseva, N., Babnigg, G., Burdette, S. C., Srajer, V., Joachimiak, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712583/
https://www.ncbi.nlm.nih.gov/pubmed/36450742
http://dx.doi.org/10.1038/s41467-022-35029-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712583/
https://www.ncbi.nlm.nih.gov/pubmed/36450742
http://dx.doi.org/10.1038/s41467-022-35029-3

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