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Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5

JmjC (Jumonji-C) domain-containing 5 (JMJD5) plays important roles in circadian regulation in plants and humans and is involved in embryonic development and cell proliferation. JMJD5 is a 2-oxoglutarate (2OG) and Fe(II) dependent oxygenase of the JmjC subfamily, which includes histone N(ε)-methyl ly...

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Detalles Bibliográficos
Autores principales: Islam, Md. Saiful, Markoulides, Marios, Chowdhury, Rasheduzzaman, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712658/
https://www.ncbi.nlm.nih.gov/pubmed/36450832
http://dx.doi.org/10.1038/s41598-022-24154-0