Protein phosphatase 2A regulates xanthine oxidase-derived ROS production in macrophages and influx of inflammatory monocytes in a murine gout model

Background: Gout is a common arthritis, due to deposition of monosodium urate (MSU) crystals which results in IL-1β secretion by tissue-resident macrophages. Xanthine oxidase (XO) catalyzes uric acid (UA) production and in the process, reactive oxygen species (ROS) are generated which contributes to...

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Detalles Bibliográficos
Autores principales: Elsayed, Sandy, Elsaid, Khaled A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712728/
https://www.ncbi.nlm.nih.gov/pubmed/36467056
http://dx.doi.org/10.3389/fphar.2022.1033520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712728/
https://www.ncbi.nlm.nih.gov/pubmed/36467056
http://dx.doi.org/10.3389/fphar.2022.1033520

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