Accurate modeling of replication rates in genome-wide association studies by accounting for Winner’s Curse and study-specific heterogeneity

Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human traits, but only a fraction of variants identified in discovery studies achieve significance in replication studies. Replication in genome-wide association studies has been well-studied...

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Detalles Bibliográficos
Autores principales: Zou, Jennifer, Zhou, Jinjing, Faller, Sarah, Brown, Robert P, Sankararaman, Sriram S, Eskin, Eleazar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713380/
https://www.ncbi.nlm.nih.gov/pubmed/36250793
http://dx.doi.org/10.1093/g3journal/jkac261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713380/
https://www.ncbi.nlm.nih.gov/pubmed/36250793
http://dx.doi.org/10.1093/g3journal/jkac261

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