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Computational analysis of prodomain cysteines in human TGF-β proteins reveals frequent loss of disulfide-dependent regulation in tumors
The functionally diverse members of the human Transforming Growth Factor-β (TGF-β) family are tightly regulated. TGF-β regulation includes 2 disulfide-dependent mechanisms—dimerization and partner protein binding. The specific cysteines participating in these regulatory mechanisms are known in just...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713452/ https://www.ncbi.nlm.nih.gov/pubmed/36214621 http://dx.doi.org/10.1093/g3journal/jkac271 |