Revisiting degron motifs in human AURKA required for its targeting by APC/C(FZR1)

Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critically dependent on destruction mediated by the anapha...

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Detalles Bibliográficos
Autores principales: Abdelbaki, Ahmed, Ascanelli, Camilla, Okoye, Cynthia N, Akman, H Begum, Janson, Giacomo, Min, Mingwei, Marcozzi, Chiara, Hagting, Anja, Grant, Rhys, De Luca, Maria, Asteriti, Italia Anna, Guarguaglini, Giulia, Paiardini, Alessandro, Lindon, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713472/
https://www.ncbi.nlm.nih.gov/pubmed/36450448
http://dx.doi.org/10.26508/lsa.202201372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713472/
https://www.ncbi.nlm.nih.gov/pubmed/36450448
http://dx.doi.org/10.26508/lsa.202201372

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