FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1

BACKGROUND: We previously report that yes-associated protein (YAP), the core downstream effector of Hippo pathway, promotes the malignant progression of glioblastoma (GBM). However, although classical regulatory mechanisms of YAP are well explored, how YAP is modulated by the Hippo-independent manne...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Wang, Kai, Fu, Jiale, Zhang, Yu, Mao, Yufei, Wang, Xu, Wang, Xiang, Yu, Rutong, Zhou, Xiuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713521/
https://www.ncbi.nlm.nih.gov/pubmed/35723276
http://dx.doi.org/10.1093/neuonc/noac156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713521/
https://www.ncbi.nlm.nih.gov/pubmed/35723276
http://dx.doi.org/10.1093/neuonc/noac156

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