Cryo‐EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

The sodium–potassium–chloride transporter NKCC1 of the SLC12 family performs Na(+)‐dependent Cl(−)‐ and K(+)‐ion uptake across plasma membranes. NKCC1 is important for regulating cell volume, hearing, blood pressure, and regulation of hyperpolarizing GABAergic and glycinergic signaling in the centra...

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Detalles Bibliográficos
Autores principales: Neumann, Caroline, Rosenbæk, Lena Lindtoft, Flygaard, Rasmus Kock, Habeck, Michael, Karlsen, Jesper Lykkegaard, Wang, Yong, Lindorff‐Larsen, Kresten, Gad, Hans Henrik, Hartmann, Rune, Lyons, Joseph Anthony, Fenton, Robert A, Nissen, Poul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713717/
https://www.ncbi.nlm.nih.gov/pubmed/36239040
http://dx.doi.org/10.15252/embj.2021110169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713717/
https://www.ncbi.nlm.nih.gov/pubmed/36239040
http://dx.doi.org/10.15252/embj.2021110169

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