An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation

A defining characteristic of mammalian prions is their capacity for self‐sustained propagation. Theoretical considerations and experimental evidence suggest that prion propagation is modulated by cell‐autonomous and non‐autonomous modifiers. Using a novel quantitative phospholipase protection assay...

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Detalles Bibliográficos
Autores principales: Avar, Merve, Heinzer, Daniel, Thackray, Alana M, Liu, Yingjun, Hruska‐Plochan, Marian, Sellitto, Stefano, Schaper, Elke, Pease, Daniel P, Yin, Jiang‐An, Lakkaraju, Asvin KK, Emmenegger, Marc, Losa, Marco, Chincisan, Andra, Hornemann, Simone, Polymenidou, Magdalini, Bujdoso, Raymond, Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713719/
https://www.ncbi.nlm.nih.gov/pubmed/36254605
http://dx.doi.org/10.15252/embj.2022112338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713719/
https://www.ncbi.nlm.nih.gov/pubmed/36254605
http://dx.doi.org/10.15252/embj.2022112338

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