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Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet

Xanthohumol (XN) improves cognition of wild-type rodents on a high-fat diet (HFD). Bile acids and ceramide levels in the liver and hippocampus might be linked to these effects. XN modulates activity of the nuclear farnesoid X receptor (FXR; also known as NR1H4), the primary receptor for bile acids....

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Detalles Bibliográficos
Autores principales: Kundu, Payel, Paraiso, Ines L., Choi, Jaewoo, Miranda, Cristobal L., Kioussi, Chrissa, Maier, Claudia S., Bobe, Gerd, Stevens, Jan F., Raber, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713832/
https://www.ncbi.nlm.nih.gov/pubmed/36353888
http://dx.doi.org/10.1242/dmm.049820