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5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages

BACKGROUND: Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading cause of death worldwide. 5-Methoxyflavone, a methylated flavonoid, is gaining increased attention for its various health benefits. In the current st...

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Detalles Bibliográficos
Autores principales: Liang, Panqiao, Wang, Linxin, Yang, Sushan, Pan, Xiping, Li, Jiashun, Zhang, Yuehan, Liang, Yueyun, Li, Jing, Zhou, Beixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713965/
https://www.ncbi.nlm.nih.gov/pubmed/36451220
http://dx.doi.org/10.1186/s12950-022-00319-6