APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice

The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astroglial function, which exert multiple effects on AD pathogenesis. Here, we show astrogli...

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Detalles Bibliográficos
Autores principales: Stephen, T. L., Breningstall, B., Suresh, S., McGill, C. J., Pike, C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714101/
https://www.ncbi.nlm.nih.gov/pubmed/36457019
http://dx.doi.org/10.1186/s12974-022-02650-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714101/
https://www.ncbi.nlm.nih.gov/pubmed/36457019
http://dx.doi.org/10.1186/s12974-022-02650-4

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