Development and characterization of a novel human CD137 agonistic antibody with anti‐tumor activity and a good safety profile in non‐human primates

CD137 (4‐1BB, TNFRSF9), an inducible T‐cell costimulatory receptor, is expressed on activated T cells, activated NK cells, Treg cells, and several innate immune cells, including DCs, monocytes, neutrophils, mast cells, and eosinophils. In animal models and clinical trials, anti‐CD137 agonistic monoc...

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Detalles Bibliográficos
Autores principales: Gao, Yingying, Yang, Teddy, Liu, Hu, Song, Ningning, Dai, Chaohui, Ding, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714380/
https://www.ncbi.nlm.nih.gov/pubmed/36176235
http://dx.doi.org/10.1002/2211-5463.13494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714380/
https://www.ncbi.nlm.nih.gov/pubmed/36176235
http://dx.doi.org/10.1002/2211-5463.13494

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