Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the human ACE2 receptor. We have developed a broadly neutralizing antibod...

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Detalles Bibliográficos
Autores principales: Jeong, Bo-Seong, Jeon, Joon Young, Lai, Chih-Jen, Yun, Hye-Yeoung, Jung, Jae U., Oh, Byung-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714666/
https://www.ncbi.nlm.nih.gov/pubmed/36466915
http://dx.doi.org/10.3389/fimmu.2022.1049867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714666/
https://www.ncbi.nlm.nih.gov/pubmed/36466915
http://dx.doi.org/10.3389/fimmu.2022.1049867

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