Intraperitoneal injection of class A TLR9 agonist enhances anti–PD-1 immunotherapy in colorectal peritoneal metastases

Peritoneal metastases are associated with a low response rate to immune checkpoint blockade (ICB) therapy. The numbers of peritoneal resident macrophages (PRMs) are reversely correlated with the response rate to ICB therapy. We have previously shown that TLR9 in fibroblastic reticular cells (FRCs) p...

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Detalles Bibliográficos
Autores principales: Jiang, Ting, Zhang, Hongji, Li, Yiming, Jayakumar, Preethi, Liao, Hong, Huang, Hai, Billiar, Timothy R., Deng, Meihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714777/
https://www.ncbi.nlm.nih.gov/pubmed/36278484
http://dx.doi.org/10.1172/jci.insight.160063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714777/
https://www.ncbi.nlm.nih.gov/pubmed/36278484
http://dx.doi.org/10.1172/jci.insight.160063

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