Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice

Patients with the renal phosphate–wasting disease X-linked hypophosphatemia (XLH) and Hyp mice, the murine homolog of XLH, are characterized by loss-of-function mutations in phosphate-regulating endopeptidase homolog X-linked (PHEX), leading to excessive secretion of the bone-derived phosphotropic h...

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Detalles Bibliográficos
Autores principales: Buck, Achim, Prade, Verena M., Kunzke, Thomas, Erben, Reinhold G., Walch, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714788/
https://www.ncbi.nlm.nih.gov/pubmed/36278488
http://dx.doi.org/10.1172/jci.insight.162138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714788/
https://www.ncbi.nlm.nih.gov/pubmed/36278488
http://dx.doi.org/10.1172/jci.insight.162138

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