Dichloroacetate and thiamine improve survival and mitochondrial stress in a C. elegans model of dihydrolipoamide dehydrogenase deficiency

Dihydrolipoamide dehydrogenase (DLD) deficiency is a recessive mitochondrial disorder caused by depletion of DLD from α-ketoacid dehydrogenase complexes. Caenorhabditis elegans animal models of DLD deficiency generated by graded feeding of dld-1(RNAi) revealed that full or partial reduction of DLD-1...

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Detalles Bibliográficos
Autores principales: Broxton, Chynna N., Kaur, Prabhjot, Lavorato, Manuela, Ganesh, Smruthi, Xiao, Rui, Mathew, Neal D., Nakamaru-Ogiso, Eiko, Anderson, Vernon E., Falk, Marni J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714793/
https://www.ncbi.nlm.nih.gov/pubmed/36278487
http://dx.doi.org/10.1172/jci.insight.156222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714793/
https://www.ncbi.nlm.nih.gov/pubmed/36278487
http://dx.doi.org/10.1172/jci.insight.156222

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