The E46K mutation modulates α-synuclein prion replication in transgenic mice

In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes familial Parkinson’s disease (PD), we previously discovered that thi...

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Detalles Bibliográficos
Autores principales: Holec, Sara A. M., Lee, Jisoo, Oehler, Abby, Batia, Lyn, Wiggins-Gamble, Aryanna, Lau, Jeffrey, Ooi, Felicia K., Merz, Gregory E., Wang, Man, Mordes, Daniel A., Olson, Steven H., Woerman, Amanda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714912/
https://www.ncbi.nlm.nih.gov/pubmed/36454879
http://dx.doi.org/10.1371/journal.ppat.1010956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714912/
https://www.ncbi.nlm.nih.gov/pubmed/36454879
http://dx.doi.org/10.1371/journal.ppat.1010956

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