Kidney tumors associated with germline mutations of FH and SDHB show a CpG island methylator phenotype (CIMP)

Germline mutations within the Krebs cycle enzyme genes fumarate hydratase (FH) or succinate dehydrogenase (SDHB, SDHC, SDHD) are associated with an increased risk of aggressive and early metastasizing variants of renal cell carcinoma (RCC). These RCCs express significantly increased levels of intrac...

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Detalles Bibliográficos
Autores principales: Ricketts, Christopher J., Killian, J. Keith, Vocke, Cathy D., Wang, Yonghong, Merino, Maria J., Meltzer, Paul S., Linehan, W. Marston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714951/
https://www.ncbi.nlm.nih.gov/pubmed/36455002
http://dx.doi.org/10.1371/journal.pone.0278108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714951/
https://www.ncbi.nlm.nih.gov/pubmed/36455002
http://dx.doi.org/10.1371/journal.pone.0278108

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