A glyco-engineering approach for site-specific conjugation to Fab glycans

Effective processes for synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio to achieve sufficient potency while avoiding aggregation or solubility problems, and 3)...

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Detalles Bibliográficos
Autores principales: Jaramillo, Maria L., Sulea, Traian, Durocher, Yves, Acchione, Mauro, Schur, Melissa J., Robotham, Anna, Kelly, John F., Goneau, Marie-France, Robert, Alma, Cepero-Donates, Yuneivy, Gilbert, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715014/
https://www.ncbi.nlm.nih.gov/pubmed/36447399
http://dx.doi.org/10.1080/19420862.2022.2149057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715014/
https://www.ncbi.nlm.nih.gov/pubmed/36447399
http://dx.doi.org/10.1080/19420862.2022.2149057

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