Protective roles of cytoplasmic p21(Cip1) (/Waf1) in senolysis and ferroptosis of lung cancer cells

OBJECTIVE: Therapy‐induced senescent cancer cells increase the expression of the cyclin‐dependent kinase inhibitors p16(Ink4a) and p21(Cip1/Waf1). Given that p21 regulates not only the cell cycle but also cell death, we investigated the roles of p21 in cell death using a p16‐negative A549 human lung...

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Detalles Bibliográficos
Autores principales: Koyanagi, Akira, Kotani, Hitoshi, Iida, Yuichi, Tanino, Ryosuke, Kartika, Irna D., Kishimoto, Koji, Harada, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715353/
https://www.ncbi.nlm.nih.gov/pubmed/36054146
http://dx.doi.org/10.1111/cpr.13326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715353/
https://www.ncbi.nlm.nih.gov/pubmed/36054146
http://dx.doi.org/10.1111/cpr.13326

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