Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling

BACKGROUND: Mitochondrial DNA (mtDNA) is a potent activator for pro‐inflammatory response. Dendritic cells (DCs) are immunosuppressed in sepsis, whether mtDNA mediates immunoparalysis in sepsis remains unknown. METHODS: The mRNAs were assessed by qPCR. Flow cytometry was used to measure the expressi...

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Detalles Bibliográficos
Autores principales: Tu, Qing, Li, Yi, Zhu, Jiali, Guo, Long, Liu, Chenchen, Liu, Lu, Yuan, Yuan, Zou, Yun, Chen, Feng, Yao, Liangfang, Li, Jinbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715356/
https://www.ncbi.nlm.nih.gov/pubmed/36106559
http://dx.doi.org/10.1111/cpr.13328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715356/
https://www.ncbi.nlm.nih.gov/pubmed/36106559
http://dx.doi.org/10.1111/cpr.13328

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