Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis

Tacrolimus (FK506) is a macrolide widely used as immunosuppressant to prevent transplant rejection. Synthetic production of FK506 is not efficient and costly, whereas the biosynthesis of FK506 is complex and the level produced by the wild type strain, Streptomyces tsukubaensis, is very low. We there...

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Detalles Bibliográficos
Autores principales: Schulz, Susann, Schall, Christoph, Stehle, Thilo, Breitmeyer, Christian, Krysenko, Sergii, Mitulski, Agnieszka, Wohlleben, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715595/
https://www.ncbi.nlm.nih.gov/pubmed/36466343
http://dx.doi.org/10.3389/fbioe.2022.1067467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715595/
https://www.ncbi.nlm.nih.gov/pubmed/36466343
http://dx.doi.org/10.3389/fbioe.2022.1067467

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