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The Combination of Electrochemistry and Microfluidic Technology in Drug Metabolism Studies

Drugs are metabolized within the liver (pH 7.4) by phase I and phase II metabolism. During the process, reactive metabolites can be formed that react covalently with biomolecules and induce toxicity. Identifying and detecting reactive metabolites is an important part of drug development. Preclinical...

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Detalles Bibliográficos
Autores principales: Grint, Isobel, Crea, Francesco, Vasiliadou, Rafaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716038/
https://www.ncbi.nlm.nih.gov/pubmed/36166688
http://dx.doi.org/10.1002/open.202200100