Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties

Novel series of amidines were synthesized via the interaction between alicyclic amines, cyclic ketones, and a highly electrophilic 4-azidoquinolin-2(1H)-ones without any catalyst or additive. All the obtained products were elucidated based on NMR spectroscopy, mass spectrometry, and elemental analys...

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Detalles Bibliográficos
Autores principales: El-Sheref, Essmat M., Tawfeek, Hendawy N., Hassan, Alaa A., Bräse, S., Elbastawesy, Mohammed A. I., Gomaa, Hesham A. M., Mostafa, Yaser A., Youssif, Bahaa G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716094/
https://www.ncbi.nlm.nih.gov/pubmed/36465858
http://dx.doi.org/10.3389/fchem.2022.1039176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716094/
https://www.ncbi.nlm.nih.gov/pubmed/36465858
http://dx.doi.org/10.3389/fchem.2022.1039176

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